Zannis V I, Kan H Y, Kritis A, Zanni E E, Kardassis D
Section of Molecular Genetics, Whitaker Cardiovascular Institute, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118-2394, USA.
Curr Opin Lipidol. 2001 Apr;12(2):181-207. doi: 10.1097/00041433-200104000-00012.
The present review summarizes recent advances in the transcriptional regulation of the human apolipoprotein genes, focusing mostly, but not exclusively, on in-vivo studies and signaling mechanisms that affect apolipoprotein gene transcription. An attempt is made to explain how interactions of transcription factors that bind to proximal promoters and distal enhancers may bring about gene transcription. The experimental approaches used and the transcriptional regulatory mechanisms that emerge from these studies may also be applicable in other gene systems that are associated with human disease. Understanding extracellular stimuli and the specific mechanisms that underlie apolipoprotein gene transcription may in the long run allow us to selectively switch on antiatherogenic genes, and switch off proatherogenic genes. This may have beneficial effects and may confer protection from atherosclerosis to humans.
本综述总结了人类载脂蛋白基因转录调控的最新进展，主要但不限于体内研究以及影响载脂蛋白基因转录的信号传导机制。试图解释与近端启动子和远端增强子结合的转录因子之间的相互作用如何引发基因转录。这些研究中使用的实验方法以及由此产生的转录调控机制也可能适用于与人类疾病相关的其他基因系统。从长远来看，了解细胞外刺激以及载脂蛋白基因转录的具体机制可能使我们能够选择性地开启抗动脉粥样硬化基因，并关闭促动脉粥样硬化基因。这可能会产生有益的效果，并为人类提供抗动脉粥样硬化的保护。
