蛋白酶体对抗原的处理
Antigen processing by the proteasome.
作者信息
Kloetzel P M
机构信息
Institut für Biochemie, Medical Faculty, Charité, Humboldt University, Monbijoustrasse 2, 10117 Berlin, Germany.
出版信息
Nat Rev Mol Cell Biol. 2001 Mar;2(3):179-87. doi: 10.1038/35056572.
DOI:10.1038/35056572
PMID:11265247
Abstract
The proteasome is an essential part of our immune surveillance mechanisms: by generating peptides from intracellular antigens it provides peptides that are then 'presented' to T cells. But proteasomes--the waste-disposal units of the cell--typically do not generate peptides for antigen presentation with high efficiency. How, then, does the proteasome adapt to serve the immune system well?
摘要
蛋白酶体是我们免疫监视机制的重要组成部分
通过从细胞内抗原生成肽段，它提供随后被“呈递”给T细胞的肽段。但是蛋白酶体——细胞的废物处理单元——通常不会高效地生成用于抗原呈递的肽段。那么，蛋白酶体是如何适应以更好地服务于免疫系统的呢？
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