Cederholm T, Larsson J, Ericsson O, Myrbäck K E, Hellgren U
Geriatriska kliniken, Huddinge Universitetssjukhus, Huddinge.
Lakartidningen. 2001 Feb 21;98(8):833-7.
From 1994 to 1998 the incidence of Clostridium difficile-associated diarrhoea (CDAD) in the Department of Geriatric Medicine, Huddinge University Hospital increased from 0.5% to 2.2% of all admissions. Corresponding figures for the whole hospital were 0.3% and 0.6%, respectively. The increase in CDAD at the Department of Geriatric Medicine was parallel with a more than doubled consumption of antibiotics. All geriatric patients with CDAD had been treated with antibiotics before onset of diarrhoea. Out of the antibiotic prescriptions 48% were a cephalosporin (mainly cefuroxim). In a matched reference group of geriatric patients 51% had been treated with antibiotics during the hospital stay. The patients with CDAD spent 27 +/- 14 days in hospital as compared to 13 +/- 9 days (P < 0.05) in the reference population.
1994年至1998年期间，胡丁厄大学医院老年医学科艰难梭菌相关性腹泻（CDAD）的发病率在所有入院患者中从0.5%升至2.2%。而整个医院的相应数字分别为0.3%和0.6%。老年医学科CDAD发病率的上升与抗生素消耗量增加一倍多同时出现。所有患CDAD的老年患者在腹泻发作前均接受过抗生素治疗。在抗生素处方中，48%为头孢菌素（主要是头孢呋辛）。在一个匹配的老年患者参照组中，51%在住院期间接受过抗生素治疗。患CDAD的患者住院时间为27±14天，而参照人群为13±9天（P<0.05）。
