Fuller C J, Barr A R, Dieppe P A
Department of Clinical Veterinary Science, University of Bristol, Langford.
Vet Rec. 2001 Feb 17;148(7):204-6. doi: 10.1136/vr.148.7.204.
An explant system was used to investigate the hypothesis that cartilage from different equine joints might respond differently to challenge with interleukin-1alpha (IL-1alpha). Pairs of normal cartilage samples were taken from the metacarpophalangeal, proximal interphalangeal and distal interphalangeal joints of six horses. One of each pair was stimulated with 10 ng/ml human recombinant IL-1alpha for three days, and the supernatants and remaining cartilage explants were analysed for their total content of glycosaminoglycans. A significantly higher percentage of glycosaminoglycans was released from the cartilage of the proximal and distal interphalangeal joints than from the metacarpophalangeal joint.
来自不同马关节的软骨对白细胞介素 -1α（IL -1α）刺激的反应可能不同。从六匹马的掌指关节、近端指间关节和远端指间关节采集成对的正常软骨样本。每对样本中的一个用10 ng/ml人重组IL -1α刺激三天，然后分析上清液和剩余软骨外植体中糖胺聚糖的总含量。近端和远端指间关节软骨释放的糖胺聚糖百分比显著高于掌指关节。
