冈田酸的C28 - C38疏水结构域对有效抑制蛋白丝氨酸 - 苏氨酸磷酸酶1和2A的重要性。
Importance of the C28-C38 hydrophobic domain of okadaic acid for potent inhibition of protein serine-threonine phosphatases 1 and 2A.
作者信息
Frydrychowski V A, Urbanek R A, Dounay A B, Forsyth C J
机构信息
Department of Chemistry, University of Minnesota, Minneapolis 55455, USA.
出版信息
Bioorg Med Chem Lett. 2001 Mar 12;11(5):647-9. doi: 10.1016/s0960-894x(01)00026-9.
Abstract
Okadaic acid is a potent inhibitor of select serine/threonine protein phosphatases. The importance of the C28-C38 hydrophobic domain of okadaic acid for inhibition of PP1 and PP2A was investigated. The hydrophobic domain is required but not sufficient for potent inhibition, and it also contributes to differential inhibition between PP1 and PP2A.
摘要
冈田酸是一种选择性丝氨酸/苏氨酸蛋白磷酸酶的强效抑制剂。研究了冈田酸的C28 - C38疏水结构域对PP1和PP2A抑制作用的重要性。该疏水结构域是强效抑制所必需的，但并不充分，并且它也导致了PP1和PP2A之间的差异抑制。
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