Harvey P D
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA.
Harv Rev Psychiatry. 2001 Mar-Apr;9(2):59-68. doi: 10.1080/10673220127879.
Although cognitive and functional impairments are very common in patients with schizophrenia, little is known about the characteristics of these impairments in older patients with the illness. Even less is known about the longitudinal course of these impairments. This article reviews the current knowledge with regard to cognitive and functional aspects of schizophrenia in late life, with a focus on the course of cognitive and functional deficits. Although the common belief has been that schizophrenia is static over the lifespan, recent evidence suggests that some patients may experience declines in their functioning over time. The predictors and course of these declines, as well as their potential underlying causes, are described in detail. Evidence regarding schizophrenia as a lifelong, dynamic brain disease is also reviewed.
尽管认知和功能障碍在精神分裂症患者中非常常见，但对于老年精神分裂症患者这些障碍的特征却知之甚少。对于这些障碍的纵向病程更是了解甚少。本文回顾了关于老年期精神分裂症认知和功能方面的现有知识，重点关注认知和功能缺陷的病程。尽管人们普遍认为精神分裂症在整个生命周期中是静止不变的，但最近的证据表明，一些患者的功能可能会随着时间的推移而下降。本文详细描述了这些下降的预测因素和病程，以及其潜在的根本原因。同时也回顾了关于精神分裂症是一种终身动态性脑部疾病的证据。
