Shimizu H, Shiga Y, Fujihara K, Ohnuma A, Itoyama Y
Department of Neurology, Tohoku University School of Medicine, Seiryomachi 1-1, Aoba-ku, Sendai 980-8574, Japan.
J Neurol Sci. 2001 Mar 15;185(1):39-42. doi: 10.1016/s0022-510x(01)00455-5.
We measured the central motor conduction time (CMCT), central sensory conduction time (CSCT), F wave and mean F wave/M wave amplitude ratio in patients with HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP) and controls. CMCTs in upper (U) and lower (L) limbs were significantly prolonged in HAM/TSP. L-CSCT was significantly prolonged in HAM/TSP, but U-CSCT in HAM/TSP and controls were not significantly different. CMCT and CSCT were significantly correlated in HAM/TSP. U-CMCT, but not L-CMCT, correlated with the clinical severity of HAM/TSP. Although F wave conduction velocity and its occurrence were normal in HAM/TSP, U- and L-mean F wave/M wave amplitude ratio tended to be higher in HAM/TSP, and the L-mean F wave/M wave amplitude ratio was significantly correlated with the L- and thoracic CMCT. These findings demonstrate that the prolongation of CMCT sensitively reflects the extension of the lesions and the disinhibition to the anterior horn cells in HAM/TSP.
我们测量了人类嗜T淋巴细胞病毒I型相关脊髓病/热带痉挛性截瘫（HAM/TSP）患者及对照组的中枢运动传导时间（CMCT）、中枢感觉传导时间（CSCT）、F波以及平均F波/M波幅比。HAM/TSP患者上肢（U）和下肢（L）的CMCT均显著延长。HAM/TSP患者的L-CSCT显著延长，但HAM/TSP患者与对照组的U-CSCT无显著差异。HAM/TSP患者的CMCT与CSCT显著相关。U-CMCT与HAM/TSP的临床严重程度相关，而L-CMCT则不然。尽管HAM/TSP患者的F波传导速度及其出现情况正常，但HAM/TSP患者的U-和L-平均F波/M波幅比往往更高，且L-平均F波/M波幅比与L-及胸段CMCT显著相关。这些发现表明，CMCT的延长敏感地反映了HAM/TSP患者病变的扩展以及对前角细胞的去抑制作用。
