Krazem A, Borde N, Béracochéa D
Université de Tizi-Ouzou, Algeria.
Pharmacol Biochem Behav. 2001 Feb;68(2):235-44. doi: 10.1016/s0091-3057(00)00444-5.
This study was aimed at determining the effects of systemic administration of diazepam and methyl beta-carboline-3-carboxylate (beta-CCM) both on spatial working memory and on emotional reactivity in mice. Results showed that diazepam and beta-CCM induced opposite effects in both memory and emotional reactivity tests. Indeed, as a function of dose, diazepam reduced anxiogenic-like reactions but increased vulnerability to interference in the memory task at a 30-s but not at a 5-s delay interval. As a function of dose, beta-CCM reduced vulnerability to interference and increased emotional reactivity, these effects being antagonised by concurrent administration of flumazenil (RO 15-1788). Thus, our study showed the bidirectional effects of these two drugs on a spatial working memory task involving a spontaneous processing of information and suggested a direct link between the emotional effects of the drugs and memory performance.
本研究旨在确定全身给予地西泮和β-咔啉-3-羧酸甲酯（β-CCM）对小鼠空间工作记忆和情绪反应性的影响。结果表明，地西泮和β-CCM在记忆和情绪反应性测试中诱导出相反的效果。事实上，作为剂量的函数，地西泮减少了焦虑样反应，但在30秒而非5秒的延迟间隔下增加了记忆任务中对干扰的易感性。作为剂量的函数，β-CCM降低了对干扰的易感性并增加了情绪反应性，这些效应被同时给予氟马西尼（RO 15-1788）所拮抗。因此，我们的研究显示了这两种药物对涉及信息自发处理的空间工作记忆任务的双向作用，并提示了药物的情绪效应与记忆表现之间的直接联系。
