Paul R H, Nash J M, Cohen R A, Gilchrist J M, Goldstein J M
Department of Psychiatry, Division of Neuropsychology, Miriam Hospital, Brown University School of Medicine, 164 Summit Ave., Room 328, Providence, Rhode Island 02906, USA.
Muscle Nerve. 2001 Apr;24(4):512-6. doi: 10.1002/mus.1034.
The cardinal symptom of myasthenia gravis (MG) is weakness of voluntary muscles, a feature that may restrict full participation in life activities. In turn, such limitations may negatively affect quality of life (QOL) and well-being among individuals with the disease. In the present study, we administered a measure of QOL to 27 patients with generalized MG. Results revealed that functional status was negatively impacted in the domains of physical functioning, energy, and general health. However, a clinically meaningful difference was evident only on perceived ability to accomplish physical tasks. The results suggest that although MG requires accommodations in physical activities, general QOL and well-being does not differ markedly from the general population.
重症肌无力（MG）的主要症状是随意肌无力，这一特征可能会限制患者充分参与生活活动。反过来，这些限制可能会对该病患者的生活质量（QOL）和幸福感产生负面影响。在本研究中，我们对27例全身型MG患者进行了生活质量测量。结果显示，身体功能、精力和总体健康等领域的功能状态受到了负面影响。然而，仅在完成体力任务的感知能力方面存在明显的临床意义差异。结果表明，尽管MG患者在体育活动中需要一些调整，但总体生活质量和幸福感与普通人群并无显著差异。
