Stojanov Aleksandar, Milošević Vuk, Đorđević Gordana, Stojanov Jelena
Clinic of Neurology, Clinical Center of Nis.
Medical Faculty, University of Nis.
Neurologist. 2019 Jul;24(4):115-120. doi: 10.1097/NRL.0000000000000238.
Myasthenia gravis (MG) affects overall quality of life (QoL). The aim of the research was to evaluate QoL in patients suffering from MG in regard to epidemiological and clinical factors of the disease.
The study included 70 patients. The severity of clinical manifestation was estimated using quantitative MG score and MG composite score. Patients were classified by using Myasthenia Gravis Foundation of America Classification. The Questionnaire of Life Quality Specific for Myasthenia Gravis-15 items (MGQOL15) is developed for QoL assessment in patients suffering from MG. In addition to the MGQOL15 revised version (MGQOL15r), a 36-item health survey of the Medical Outcomes Study Short Form (SF36) questionnaire, the Hamilton scales for the assessment of anxiety (HAM-A), and depression (HAM-D) were also used.
MGQOL15r scores are negatively correlated with SF36 scores and positively correlated with scores on HAM-A and HAM-D scales (P<0.001). Patients with longer disease duration and severe clinical manifestation often manifest anxiety, depression, and have poorer QoL (P<0.05). In relation to the presence of the anti-nAchR antibody, statistically significant differences were found in relation to the summed scores on scales for assessing QoL, as well as on a HAM-A scale (P<0.05). Physical workers and unemployed patients had worse scores in relation to retired and administrators/intellectual workers on all scales (P<0.001).
MGQOL15r is a life quality assessment questionnaire that could be used in routine practice in patients with MG. It is much simpler for use in these patients than SF36 and provides relevant data.
重症肌无力（MG）会影响整体生活质量（QoL）。本研究的目的是评估重症肌无力患者的生活质量与该疾病的流行病学及临床因素之间的关系。
该研究纳入了70名患者。使用定量MG评分和MG综合评分来评估临床表现的严重程度。采用美国重症肌无力基金会分类法对患者进行分类。重症肌无力特异性生活质量问卷-15项（MGQOL15）用于评估重症肌无力患者的生活质量。除了MGQOL15修订版（MGQOL15r）外，还使用了医学结局研究简表（SF36）问卷中的36项健康调查、汉密尔顿焦虑量表（HAM-A）和汉密尔顿抑郁量表（HAM-D）。
MGQOL15r评分与SF36评分呈负相关，与HAM-A和HAM-D量表评分呈正相关（P<0.001）。病程较长且临床表现严重的患者常表现出焦虑、抑郁，生活质量较差（P<0.05）。关于抗nAchR抗体的存在，在生活质量评估量表总分以及HAM-A量表上发现了统计学上的显著差异（P<0.05）。体力劳动者和失业患者在所有量表上的得分均低于退休人员和行政人员/脑力劳动者（P<0.001）。
MGQOL15r是一种可用于重症肌无力患者日常临床实践的生活质量评估问卷。与SF36相比，它在这些患者中使用起来要简单得多，并能提供相关数据。
