Segal M, Clarke D J
The Scripps Research Institute, La Jolla, CA 92037, USA.
Bioessays. 2001 Apr;23(4):307-10. doi: 10.1002/bies.1044.
Although alterations in Ras signalling are found in about 30% of human cancers, the transforming activity of oncogenic Ras is not fully understood. In a recent paper, a putative Ras1 effector in S. pombe, named Scd1, was reported to localize to mitotic spindles. Scd1 physically associates with Moe1, a factor that may contribute to the inherent instability of microtubules (MTs) and appears to be needed for proper spindle function. Altered MT dynamics within the spindle are likely to affect spindle assembly and chromosome capture, processes that need to be delicately controlled if cells are to guard against genome instability and transformation. BioEssays 23:307-310, 2001.
虽然在约30%的人类癌症中发现了Ras信号通路的改变，但致癌Ras的转化活性尚未完全明确。在最近一篇论文中，据报道粟酒裂殖酵母中一种假定的Ras1效应蛋白Scd1定位于有丝分裂纺锤体。Scd1与Moe1直接相互作用，Moe1可能是导致微管固有不稳定性的一个因素，并且似乎是正常纺锤体功能所必需的。纺锤体内微管动力学的改变可能会影响纺锤体组装和染色体捕获，如果细胞要防止基因组不稳定和转化，这些过程需要精确控制。《生物论文》23:307 - 310，2001年。
