Auernhammer C J, Bousquet C, Chesnokova V, Melmed S
Cedars-Sinai Medical Center, 8700 Beverly Blvd., Room 2015, Los Angeles, CA 90048, USA.
Ann N Y Acad Sci. 2000;917:658-64. doi: 10.1111/j.1749-6632.2000.tb05431.x.
Several members of the newly characterized family of suppressor of cytokine signaling (SOCS) proteins-such as SOCS-1, SOCS-3, and CIS-act as negative regulators of the cytokine-induced Jak-STAT signaling cascade. The expression of SOCS proteins is stimulated by a variety of cytokines and hormones in a tissue-specific manner. This article reviews our current understanding of SOCS proteins and their role as modulators of neuroimmunoendocrine functions, for example, in signaling of leptin, growth hormone, and prolactin, specially focusing on the impact of SOCS proteins on corticotroph leukemia inhibitory factor (LIF) signaling. LIF, a member of the gp130 sharing cytokine family, modulates pituitary development, POMC gene expression, and ACTH secretion. Current data on the negative autoregulatory function of the suppressor of cytokine signaling, SOCS-3, in LIF-induced POMC gene expression and ACTH secretion are extensively discussed.
细胞因子信号转导抑制因子（SOCS）蛋白新鉴定家族的几个成员，如SOCS-1、SOCS-3和CIS，作为细胞因子诱导的Jak-STAT信号级联反应的负调节因子发挥作用。SOCS蛋白的表达以组织特异性方式受到多种细胞因子和激素的刺激。本文综述了我们目前对SOCS蛋白及其作为神经免疫内分泌功能调节剂作用的理解，例如在瘦素、生长激素和催乳素信号传导方面，特别关注SOCS蛋白对促肾上腺皮质激素释放激素白血病抑制因子（LIF）信号传导的影响。LIF是gp130共享细胞因子家族的成员，调节垂体发育、阿黑皮素原（POMC）基因表达和促肾上腺皮质激素（ACTH）分泌。本文广泛讨论了细胞因子信号转导抑制因子SOCS-3在LIF诱导的POMC基因表达和ACTH分泌中的负自调节功能的现有数据。
