Shiau Y C, Hsieh J F, Tsai S C, Ho Y J, Sun S S, Kao C H
Department of Nuclear Medicine, Far East Memorial Hospital, Taipei.
Anticancer Res. 2000 Sep-Oct;20(5C):3751-4.
This study evaluated the clinical role of Tc-99m-methoxyisobtylisonitrile (Tc-MIBI) single photon emission computed tomography (SPECT) of the chest in the detection of mediastinal lymph node (MLN) metastasis in patients with non-small cell lung cancer (NSCLC). Twenty-five patients with proven NSCLC were enrolled in this study. Each of the patients received computed tomography (CT) of the chest and Tc-MIBI SPECT of the chest for presurgical staging. A postsurgical pathologic diagnosis was made and these patients were evaluated for the study of mediastinal lymph nde (MLN) involvement. Meanwhile, 10 volunteers also accepted Tc-MIBI SPECT of the chest for comparison. The results showed that the diagnostic sensitivity, specificity and accuracy of Tc-MIBI chest SPECT were 81.8%, 85.7% and 84% and for chest CT they are 36.3%, 85.7% and 64%, respectively. Our results indicated that Tc-MIBI chest SPECT was more sensitive and accurate than chest CT in the evaluation and detection of MLN involvement in the NSCLC patients.
本研究评估了锝-99m-甲氧基异丁基异腈（Tc-MIBI）胸部单光子发射计算机断层扫描（SPECT）在检测非小细胞肺癌（NSCLC）患者纵隔淋巴结（MLN）转移中的临床作用。25例经证实的NSCLC患者纳入本研究。每位患者术前行胸部计算机断层扫描（CT）和胸部Tc-MIBI SPECT检查进行术前分期。术后进行病理诊断，并对这些患者进行纵隔淋巴结（MLN）受累情况的研究评估。同时，10名志愿者也接受胸部Tc-MIBI SPECT检查用于对比。结果显示，胸部Tc-MIBI SPECT的诊断敏感性、特异性和准确性分别为81.8%、85.7%和84%，而胸部CT的诊断敏感性、特异性和准确性分别为36.3%、85.7%和64%。我们的结果表明，在评估和检测NSCLC患者的MLN受累情况方面，胸部Tc-MIBI SPECT比胸部CT更敏感、准确。
