Date Y, Nakazato M, Matsukura S
Nihon Rinsho. 2001 Mar;59(3):427-30.
The hypothalamus is the most important region in the control of food intake and body weight. The ventromedial 'satiety center' and lateral hypothalamic 'feeding center' have been implicated in the regulation of feeding and energy homeostasis by various studies of brain lesions. Orexins(orexin A and orexin B) and melanin-concentrating hormone (MCH), whose intracerebroventricular injections increase food intake, are localized in the lateral hypothalamus and provide diffuse projections throughout the brain. Orexins and MCH neurons have a coextensive distribution, but are not colocalized. Orexins and MCH may affect feeding behavior through distinct neuronal pathways. We here describe the effect of orexins and MCH on feeding behavior from the physiological, neuroanatomical and molecular studies.
下丘脑是控制食物摄入和体重的最重要区域。通过对脑损伤的各种研究表明，腹内侧“饱腹感中枢”和下丘脑外侧“进食中枢”参与了进食和能量稳态的调节。食欲素（食欲素A和食欲素B）和促黑素细胞激素（MCH），其脑室内注射可增加食物摄入量，它们位于下丘脑外侧，并向整个大脑提供弥散性投射。食欲素和MCH神经元分布广泛，但并不共定位。食欲素和MCH可能通过不同的神经通路影响进食行为。我们在此从生理学、神经解剖学和分子研究方面描述食欲素和MCH对进食行为的影响。
