Marte A, Cotrufo A M, Del Monaco C, Di Iorio G, De Pasquale M
Dipartimento di Pediatria, Chirurgia Pediatrica Secondo Ateneo, Università degli Studi, Napoli.
Minerva Pediatr. 2000 Dec;52(12):713-7.
Buccal mucosal grafts are widely used in the treatment of primary hypospadias and urethral stenosis owing to their elasticity, optimal attachment, possibility of generous harvesting and easy preparation. The aim of this study was to check whether buccal mucosal flaps are also valuable in redo surgery for hypospadias complicated by large breaks in the urethra and with scarce residual genital tissue.
Fourteen patients aged between 3 and 11 years old (mean age 6.6) were selected and operated between December 1993 and June 1999. The patients presented extensive fistulous tracts, roughly ellipsoidal in shape and with a maximum diameter of between 7 and 42 mm (mean length 18 mm). The original technique was: Duplay (7 patients); Onlay buccal graft (1 patient); Snodgrass (1 patient); Tubulised preputial flap (2 patients); Onlay preputial graft (2 patients); Tubulised vesical mucosal flap (1 patient). The mucosal flap, taken from the lower lip, was used to cover the gap as an onlay patch and recovered with residual genital skin with the interposition, where possible, of a de-epithelised flap.
An optimal cosmetic and functional result was achieved in 10/14 cases with flowmetry > 25 percentile according to Toguri nomograms. Three patients presented fistulas: one punctiform fistula resolved spontaneously. The other two cases resolved after corrective surgery. One patient showed meatal regression with slight stenosis that was resolved with MAGPI.
These results appear to be encouraging. Buccal mucosal graft may represent a valid alternative also in the treatment of secondary hypospadia with large breaks in the urethra. No complication was reported in the harvesting area, even if this was carried out at a second stage in the labial area.
由于颊黏膜移植物具有弹性、附着性佳、取材丰富且易于制备等特点,其在原发性尿道下裂和尿道狭窄的治疗中被广泛应用。本研究的目的是检验颊黏膜瓣在因尿道大段缺损且残留生殖组织稀少而导致的尿道下裂再次手术中是否也具有价值。
选取14例年龄在3至11岁之间(平均年龄6.6岁)的患者,于1993年12月至1999年6月期间进行手术。这些患者存在广泛的瘘管,大致呈椭圆形,最大直径在7至42毫米之间(平均长度18毫米)。原手术方式包括:杜普雷手术(7例);颊黏膜覆盖术(1例);斯诺德格拉斯手术(1例);管状包皮瓣手术(2例);包皮覆盖术(2例);管状膀胱黏膜瓣手术(1例)。取自下唇的黏膜瓣被用作覆盖缺损的贴补片,并尽可能用去上皮化的皮瓣隔开,再用残留的生殖皮肤覆盖。
根据托古里 nomograms,14例中有10例获得了最佳的美容和功能效果,尿流率超过第25百分位数。3例出现瘘管:1例点状瘘管自行愈合。另外2例在矫正手术后愈合。1例患者出现尿道口退缩并伴有轻度狭窄,通过尿道口成形术得到解决。
这些结果似乎令人鼓舞。颊黏膜移植物在治疗尿道大段缺损的继发性尿道下裂中也可能是一种有效的替代方法。即使在唇部区域进行二期取材,取材区域也未报告并发症。