Sakurama T, Nakamura T, Koyama J
J Biochem. 1975 Feb;77(2):265-8. doi: 10.1093/oxfordjournals.jbchem.a130723.
Disappearance of rabbit EgG and its Fc fragment from the injected sites in skin and also the relationship to reverse passive cutaneous anaphylaxis (RPCA) were studied using guinea pigs. Rabbit IgG and its Fc fragment, trace labelled with -125-I, disappeared from the injected sites with half-lives of 12--14 and 6--7 hr, respectively. The shorter half-life of the Fc fragment explained why its activity to provoke RPCA disappeared more rapidly than that of intact IgG as the sensitization period was prolonged. The ability to provoke RPCA did not seem to influence the persistence of Fc fragment in the sites, since F(ab')2 as well as Fab fragments had the same half-life as Fc fragment.
利用豚鼠研究了兔IgG及其Fc片段在皮肤注射部位的消失情况以及与反向被动皮肤过敏反应（RPCA）的关系。用¹²⁵I微量标记的兔IgG及其Fc片段分别以12 - 14小时和6 - 7小时的半衰期从注射部位消失。Fc片段较短的半衰期解释了为什么随着致敏期延长，其引发RPCA的活性比完整IgG更快消失。引发RPCA的能力似乎不影响Fc片段在注射部位的持续存在，因为F(ab')₂和Fab片段与Fc片段具有相同的半衰期。
