载脂蛋白E在心脏手术后认知功能衰退中的作用。
The role of apolipoprotein E in cognitive decline after cardiac operation.
作者信息
Steed L, Kong R, Stygall J, Acharya J, Bolla M, Harrison M J, Humphries S E, Newman S P
机构信息
Department of Psychiatry and Behavioural Sciences, Centre for Cardiovascular Genetics, University College London, England.
出版信息
Ann Thorac Surg. 2001 Mar;71(3):823-6. doi: 10.1016/s0003-4975(00)02511-x.
BACKGROUND
Recently, Tardiff and colleagues have suggested that the presence of the apolipoprotein E, epsilon4 allele was associated with increased likelihood of cognitive decline after coronary artery bypass grafting. The objective of the current study was to replicate this earlier work using an increased sample size. The increased sample also enabled an analysis by individual genotype in cognitive decline after coronary artery bypass grafting.
METHODS
Apolipoprotein E genotyping was performed on 111 individuals undergoing coronary artery bypass grafting. Each participant underwent a battery of nine neuropsychological tests before operation and 4 to 7 weeks after operation.
RESULTS
Cognitive decline, assessed by both continuous Z change scores and two categoric measures of cognitive deficit, was not significantly associated with either individual apolipoprotein E genotypes or categorization by the presence or absence of the epsilon4 allele. The examination of potential moderating factors did not alter this finding.
CONCLUSIONS
This study suggests that the epsilon4 allele is not associated with cognitive decline in the weeks after coronary artery bypass grafting.
背景
最近，塔尔迪夫及其同事指出，载脂蛋白E ε4等位基因的存在与冠状动脉搭桥术后认知功能下降的可能性增加有关。本研究的目的是通过增加样本量来重复这项早期研究。增加的样本量还使得能够对冠状动脉搭桥术后认知功能下降的个体基因型进行分析。
方法
对111例行冠状动脉搭桥术的患者进行载脂蛋白E基因分型。每位参与者在手术前和术后4至7周接受一系列九项神经心理学测试。
结果
通过连续Z变化分数和两种认知缺陷分类测量评估的认知功能下降，与个体载脂蛋白E基因型或ε4等位基因的存在与否分类均无显著关联。对潜在调节因素的检查并未改变这一发现。
结论
本研究表明，ε4等位基因与冠状动脉搭桥术后数周内的认知功能下降无关。
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