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Cdc7 kinase complex: a key regulator in the initiation of DNA replication.细胞周期蛋白依赖性激酶7激酶复合物：DNA复制起始的关键调节因子。
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本文引用的文献

1
Schizosaccharomyces pombe Hsk1p is a potential cds1p target required for genome integrity.粟酒裂殖酵母Hsk1p是基因组完整性所需的潜在cds1p靶点。
Mol Cell Biol. 2000 Nov;20(21):7922-32. doi: 10.1128/MCB.20.21.7922-7932.2000.
2
Initiation of eukaryotic DNA replication: origin unwinding and sequential chromatin association of Cdc45, RPA, and DNA polymerase alpha.真核生物DNA复制的起始：起始点解旋以及Cdc45、RPA和DNA聚合酶α与染色质的顺序结合
Mol Cell. 2000 Apr;5(4):617-27. doi: 10.1016/s1097-2765(00)80241-5.
3
Xenopus cdc7 function is dependent on licensing but not on XORC, XCdc6, or CDK activity and is required for XCdc45 loading.非洲爪蟾cdc7的功能依赖于复制许可，但不依赖于XORC、XCdc6或CDK活性，并且是XCdc45装载所必需的。
Genes Dev. 2000 Jun 15;14(12):1528-40.
4
Human Cdc7-related kinase complex. In vitro phosphorylation of MCM by concerted actions of Cdks and Cdc7 and that of a criticial threonine residue of Cdc7 bY Cdks.人源Cdc7相关激酶复合物。Cdk与Cdc7协同作用对MCM进行体外磷酸化，以及Cdk对Cdc7关键苏氨酸残基的磷酸化。
J Biol Chem. 2000 Sep 15;275(37):29042-52. doi: 10.1074/jbc.M002713200.
5
Cdc7p-Dbf4p becomes famous in the cell cycle.Cdc7p-Dbf4p在细胞周期中声名远扬。
J Cell Sci. 2000 Jun;113 ( Pt 12):2111-7. doi: 10.1242/jcs.113.12.2111.
6
Hierarchy of S-phase-promoting factors: yeast Dbf4-Cdc7 kinase requires prior S-phase cyclin-dependent kinase activation.S期促进因子的层级结构：酵母Dbf4-Cdc7激酶需要先激活S期细胞周期蛋白依赖性激酶
Mol Cell Biol. 2000 Jun;20(11):3795-806. doi: 10.1128/MCB.20.11.3795-3806.2000.
7
Assembly of a complex containing Cdc45p, replication protein A, and Mcm2p at replication origins controlled by S-phase cyclin-dependent kinases and Cdc7p-Dbf4p kinase.由S期细胞周期蛋白依赖性激酶和Cdc7p-Dbf4p激酶控制，在复制起点组装包含Cdc45p、复制蛋白A和Mcm2p的复合物。
Mol Cell Biol. 2000 May;20(9):3086-96. doi: 10.1128/MCB.20.9.3086-3096.2000.
8
Premature structural changes at replication origins in a yeast minichromosome maintenance (MCM) mutant.酵母微小染色体维持（MCM）突变体中复制起点的过早结构变化。
J Biol Chem. 2000 Jun 16;275(24):18011-21. doi: 10.1074/jbc.M909787199.
9
Dbf4p, an essential S phase-promoting factor, is targeted for degradation by the anaphase-promoting complex.Dbf4p是一种促进S期的必需因子，它被后期促进复合物靶向降解。
Mol Cell Biol. 2000 Jan;20(1):242-8. doi: 10.1128/MCB.20.1.242-248.2000.
10
Activation of Rad53 kinase in response to DNA damage and its effect in modulating phosphorylation of the lagging strand DNA polymerase.Rad53激酶在响应DNA损伤时的激活及其在调节滞后链DNA聚合酶磷酸化中的作用。
EMBO J. 1999 Nov 15;18(22):6561-72. doi: 10.1093/emboj/18.22.6561.

Cdc7/Dbf4蛋白激酶：S期检查点的作用靶点？

The Cdc7/Dbf4 protein kinase: target of the S phase checkpoint?

作者信息

Jares P, Donaldson A, Blow J J

机构信息

Department of Biochemistry, University of Dundee, UK.

出版信息

EMBO Rep. 2000 Oct;1(4):319-22. doi: 10.1093/embo-reports/kvd076.

DOI:10.1093/embo-reports/kvd076
PMID:11269496
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1083750/
Abstract

Cdc7/Dbf4 is a protein kinase that is required for the initiation of DNA replication in eukaryotes. Recent work has provided new clues to the role that Cdc7/Dbf4 plays in this process. A range of other observations suggest that Cdc7/Dbf4 also plays another, less well characterized, role in checkpoint function and in the maintenance of genomic integrity. In this review we attempt to bring together new information to explain how Cdc7/Dbf4 may perform these two distinct functions.

摘要

Cdc7/Dbf4是一种蛋白激酶，真核生物DNA复制起始时需要它。最近的研究为Cdc7/Dbf4在此过程中所起的作用提供了新线索。一系列其他观察结果表明，Cdc7/Dbf4在检查点功能和基因组完整性维持方面也发挥着另一个特征不太明确的作用。在本综述中，我们试图整合新信息，以解释Cdc7/Dbf4如何执行这两种不同的功能。