Boussofara M, Bracco D, Ravussin P
Institute Salah Azaiz, Tunis, Tunisia.
Eur J Anaesthesiol. 2001 Feb;18(2):75-8. doi: 10.1046/j.1365-2346.2001.00782.x.
This study compares the effect of oral clonidine vs. hydroxyzine on the haemodynamic and catecholamine responses to microlaryngoscopy.
Thirty-five ASA II-III patients were included in this double-blind randomized trial. The patients received either hydroxyzine 1 mg kg-1 (n = 18) or clonidine 3 micrograms kg-1 (n = 17) for their oral premedication 100 min before an intravenous induction of anaesthesia using propofol (2-3 mg kg-1) and fentanyl (2 micrograms kg-1). Arterial pressure and heart rate were measured before premedication, and throughout the procedure and recovery. Plasma catecholamine levels were determined before premedication, after induction, and 1.5, 30 and 120 min after laryngoscopy.
Mean arterial pressure was significantly lower after clonidine, whereas there was no difference in heart rate and plasma catecholamine levels between the two groups.
Clonidine for premedication significantly decreased mean arterial pressure during microlaryngoscopy and the following recovery phase but did not modify the overall haemodynamic response to the suspension microlaryngoscopic nociceptive stimulus.
本研究比较口服可乐定与羟嗪对显微喉镜检查时血液动力学及儿茶酚胺反应的影响。
35例美国麻醉医师协会（ASA）分级为II-III级的患者纳入本双盲随机试验。在使用丙泊酚（2-3mg/kg）和芬太尼（2μg/kg）静脉诱导麻醉前100分钟，患者接受羟嗪1mg/kg（n = 18）或可乐定3μg/kg（n = 17）进行口服术前用药。在术前用药前、整个手术过程及恢复过程中测量动脉压和心率。在术前用药前、诱导后以及喉镜检查后1.5、30和120分钟测定血浆儿茶酚胺水平。
可乐定用药后平均动脉压显著降低，而两组间心率和血浆儿茶酚胺水平无差异。
术前使用可乐定可显著降低显微喉镜检查期间及随后恢复阶段的平均动脉压，但未改变对悬吊式显微喉镜伤害性刺激的整体血液动力学反应。
