Ece A, Gürkan F, Haspolat K, Derman O, Kirbaş G
Dicle University Hospital, Department of Pediatrics, Turkey.
Allergol Immunopathol (Madr). 2000 Sep-Oct;28(5):255-60.
Carbon monoxide (CO) in expired air has been reported to be an indirect measurement for the quantity of passive smoking. Since endogen CO is produced in inflammatory processes and inflammation is the main pathogenetic mechanism of asthma, it was aimed to investigate the relationship between the intensity of passive smoking and CO concentration in expired air of healthy and asthmatic children.
The study was performed in the outpatient pediatrics clinics and day care centers. Knowledge about indoor smoking habits were obtained from parents. The exhaled CO concentrations were measured by a portable device in 235 healthy (mean age, 4.4 +/- 2.3 years) and 54 asthmatic (mean age, 4.5 +/- 1.7 years) children. Children with no smoking parents had the lowest exhaled CO concentrations. Significant relationships were found between the number of smoking cigarettes in the house and exhaled CO concentrations in both healthy (p = 0.003) and asthmatic (p = 0.01) children. Carbon monoxide concentrations were higher in asthmatic children than healthy ones (mean +/- SD, 1.32 +/- 1.50 ppm and 0.86 +/- 1.35 ppm, respectively, p = 0.028) if their parental smoking habits were not taken into account. Asthmatic children of non-smoking parents had higher CO concentrations than healthy subjects of non-smoking parents (1.05 +/- 1.55 ppm vs 0.37 +/- 0.53 ppm, p = 0.01). On the other hand, asthmatic children who has no smoking parents and did not receive inhaled steroids had significantly higher CO concentrations (1.75 +/- 1.45 ppm) than those who received steroids (0.58 +/- 0.65 ppm, p = 0.024).
Exhaled CO can be used as an indicator of passive smoking in children. Higher expired CO of asthmatic children may reflect inflammation of the lung in asthma.
据报道，呼出气体中的一氧化碳（CO）是被动吸烟量的一种间接测量指标。由于内源性CO在炎症过程中产生，且炎症是哮喘的主要发病机制，因此旨在研究健康儿童和哮喘儿童被动吸烟强度与呼出气体中CO浓度之间的关系。
该研究在儿科门诊和日托中心进行。从家长处获取有关室内吸烟习惯的信息。使用便携式设备测量了235名健康儿童（平均年龄4.4±2.3岁）和54名哮喘儿童（平均年龄4.5±1.7岁）呼出的CO浓度。父母不吸烟的儿童呼出的CO浓度最低。在健康儿童（p = 0.003）和哮喘儿童（p = 0.01）中，均发现家中吸烟数量与呼出的CO浓度之间存在显著关系。如果不考虑父母的吸烟习惯，哮喘儿童的一氧化碳浓度高于健康儿童（分别为平均±标准差1.32±1.50 ppm和0.86±1.35 ppm，p = 0.028）。父母不吸烟的哮喘儿童的CO浓度高于父母不吸烟的健康儿童（1.05±1.55 ppm对0.37±0.53 ppm，p = 0.01）。另一方面，父母不吸烟且未接受吸入类固醇治疗的哮喘儿童的CO浓度（1.75±1.45 ppm）显著高于接受类固醇治疗的儿童（0.58±0.65 ppm，p = 0.024）。
呼出的CO可作为儿童被动吸烟的指标。哮喘儿童呼出的较高CO水平可能反映了哮喘时肺部的炎症。
