Lamboley G, Mandel R, Müller S, Douard P, Métral S, Durand P
Service de réanimation pédiatrique, hôpital Bicêtre, 78, avenue du Général-Leclerc, 94275 Le Kremlin-Bicêtre, France.
Arch Pediatr. 2001 Mar;8(3):286-9. doi: 10.1016/s0929-693x(00)00197-4.
Three cases of an outbreak of familial foodborne botulism are reported. The food incriminated could not be identified despite a careful investigation into the food history of the patients. The outcome was good following endotracheal ventilation and botulism antitoxin trivalent therapy.
In France, foodborne botulism is an uncommon public health disease, and with a good prognosis when the diagnosis is promptly performed. The value of emergency electromyographic findings is emphasized, particularly when the repetitive stimulation of the motor nerve shows a presynaptic block of neuromuscular transmission. Management depends on the symptomatology, and trivalent antitoxin therapy is the only specific treatment.
报告了三例家族性食源性肉毒中毒暴发事件。尽管对患者的饮食史进行了仔细调查,但仍无法确定引发中毒的食物。经气管插管通气和三价肉毒中毒抗毒素治疗后,预后良好。
在法国,食源性肉毒中毒是一种罕见的公共卫生疾病,若能及时诊断,预后良好。强调了紧急肌电图检查结果的价值,尤其是当运动神经重复刺激显示神经肌肉传递的突触前阻滞时。治疗取决于症状,三价抗毒素治疗是唯一的特异性治疗方法。