Chilmonczyk Z, Ksycińska H, Krzywda J, Iskra-Jopa J
Drug Institute, ul. Chelmska 30/34, 00-725 Warsaw, Poland.
Chirality. 2001;13(3):148-52. doi: 10.1002/1520-636X(2001)13:3<148::AID-CHIR1012>3.0.CO;2-Y.
The behavior of a series of 3-amino-2-oxazolidinone derivatives with a potential hypnotic activity on achiral (octadecylsilane) and chiral (cellulose tris(4-methylbenzoate)) stationary phases was examined. The compounds differed in the composition of a substituted aromatic ring containing different substituents in different positions. It was possible to resolve all the compounds with selectivity 1.11 < or = alpha < or = 2.74. The enantiodifferentiating power of substituents was correlated to their electron donating ability and position in the aromatic ring.
研究了一系列对非手性（十八烷基硅烷）和手性（三（4-甲基苯甲酸）纤维素）固定相具有潜在催眠活性的3-氨基-2-恶唑烷酮衍生物的行为。这些化合物在不同位置含有不同取代基的取代芳环组成上有所不同。所有化合物都能以1.11≤α≤2.74的选择性拆分。取代基的对映体区分能力与其给电子能力和在芳环中的位置相关。
