Mundle S D, Teni T R, Sheth N A
Endocrinology Unit, Cancer Research Institute, Tata Memorial Centre, Parel, Bombay, India.
J Clin Lab Immunol. 1992;38(4):187-93.
This report deals with the effect of purified HSPI (10.7 kDa single chain prostatic peptide of 94 amino acids) on PHA-stimulated proliferation of peripheral blood mononuclear cells (PBMNC). HSPI was found to inhibit the incorporation of 3H-thymidine by PHA-stimulated PBMNC in a dose-dependent manner, albeit with the requisite of pretreatment of cells with HSPI. A maximum inhibition was observed on pretreatment for 30 min. These studies thus indicate that HSPI may be interfering with the very early events of PHA-induced signal transduction process in PBMNC.
本报告探讨了纯化的HSPI（一种由94个氨基酸组成的10.7 kDa单链前列腺肽）对PHA刺激的外周血单个核细胞（PBMNC）增殖的影响。结果发现，HSPI能以剂量依赖的方式抑制PHA刺激的PBMNC掺入3H-胸腺嘧啶核苷，不过细胞需要用HSPI进行预处理。预处理30分钟时观察到最大抑制作用。因此，这些研究表明，HSPI可能干扰了PBMNC中PHA诱导的信号转导过程的早期事件。
