Yair D, Eshed-Englender T, Kupferminc M J, Geva E, Frenkel J, Sherman D
Department of Obstetrics and Gynecology, Ma'ayani Hyeshua Hospital, Bnai Brak, Israel.
Am J Reprod Immunol. 2001 Mar;45(3):180-7. doi: 10.1111/j.8755-8920.2001.450310.x.
To investigate whether inhibin A, inhibin B, and activin A serum levels are altered in women with preeclampsia.
Serum samples of 20 women with preeclampsia (study group) and 20 normotensive pregnant women, matched for maternal and gestational age and parity, were assayed for inhibin A, inhibin B and activin A by specific enzyme-linked immunosorbent assay.
Median serum concentrations of inhibin A and activin A were significantly higher among women with preeclampsia than in women with normotensive pregnancies, while inhibin B levels were comparable in both groups. Activin A levels were positively correlated with those of inhibins A and B, and inhibin A levels were positively correlated with diastolic blood pressure and inhibin B concentration in the study group.
Inhibin A and activin A, but not inhibin B, serum levels are markedly increased in women with preeclampsia. These hormones might serve as an endocrine marker for preeclampsia.
研究子痫前期女性血清抑制素A、抑制素B和激活素A水平是否发生改变。
采用特异性酶联免疫吸附测定法，对20例子痫前期女性（研究组）及20例年龄、孕周和产次相匹配的血压正常孕妇的血清样本进行抑制素A、抑制素B和激活素A检测。
子痫前期女性血清抑制素A和激活素A的中位数浓度显著高于血压正常孕妇，而两组抑制素B水平相当。研究组中，激活素A水平与抑制素A和抑制素B水平呈正相关，抑制素A水平与舒张压及抑制素B浓度呈正相关。
子痫前期女性血清抑制素A和激活素A水平显著升高，而抑制素B水平未升高。这些激素可能作为子痫前期的内分泌标志物。
