Santos A F, Ferraz P A, de Abreu F C, Chiari E, Goulart M O, Sant'Ana A E
Planta Med. 2001 Feb;67(1):92-3. doi: 10.1055/s-2001-10877.
The activity of the potassium salt of lapachol against the snail Biomphalaria glabrata and its egg masses was tested. The obtained IC50 values (2.70 ppm and 1.43 ppm, respectively) are indicative of a strong activity. Lapachol derivatives were also assayed against infective trypomastigote blood forms of T. cruzi and the triacetoxy derivative of reduced lapachol showed relevant trypanocidal activity, killing 95.7% of the parasites at the concentration of 42 microg/mL.
测试了拉帕醇钾盐对光滑双脐螺及其卵块的活性。获得的IC50值（分别为2.70 ppm和1.43 ppm）表明其具有很强的活性。还对拉帕醇衍生物针对克氏锥虫感染性锥鞭毛体血液形态进行了测定，还原型拉帕醇的三乙酰氧基衍生物显示出相关的杀锥虫活性，在浓度为42微克/毫升时可杀死95.7%的寄生虫。
