Schade D S, Eaton R P
J Clin Endocrinol Metab. 1975 Apr;40(4):732-5. doi: 10.1210/jcem-40-4-732.
The tissue response to exogenously administered glucagon was examined in 5 obese subjects (180 plus or minus 20 percent ideal body weight) and compared with the response in 5 normal weight controls (plus or minus 10 percent of ideal body weight). In all control subjects, glucagon (1 mug/kg) caused an increase in plasma free fatty acids and betahydroxybutyrate concentrations. In contrast, not only did the obese subjects fail to demonstrate a similar catabolic response, but 4 of the 5 obese subjects actually responded with a depression of plasma free fatty acid concentration and 3 of the 5, a decrease in betahydroxybutyrate. The potential mechanisms responsible for this defect are discussed, and it is suggested that the observation of an abnormal tissue response to a pharmacological stimulus warrants further investigation utilizing physiological lipolytic stimuli.
对5名肥胖受试者（体重为理想体重的180%±20%）外源性给予胰高血糖素后的组织反应进行了检测，并与5名正常体重对照者（体重为理想体重的±10%）的反应进行了比较。在所有对照受试者中，胰高血糖素（1微克/千克）导致血浆游离脂肪酸和β-羟基丁酸浓度升高。相比之下，肥胖受试者不仅未能表现出类似的分解代谢反应，而且5名肥胖受试者中有4名实际出现血浆游离脂肪酸浓度降低，5名中有3名β-羟基丁酸降低。讨论了导致这种缺陷的潜在机制，并提出观察到对药理刺激的异常组织反应值得利用生理性脂解刺激进行进一步研究。
