常咯啉对豚鼠和兔单个心肌细胞钾电流的影响。
Effects of changrolin on potassium currents in guinea pig and rabbit single heart cells.
作者信息
Lü L L
机构信息
Department of Physiology, College of Medicine, Xiamen University, Xiamen 361005, China.
出版信息
Zhongguo Yao Li Xue Bao. 1999 Nov;20(11):1015-8.
AIM
To elucidate whether or not changrolin (CRL) modifies the potassium currents (ITO, IK, and IKl) in myocardial cells.
METHODS
A tight seal whole-cell patch-clamp technique was used to record ITO, IK, and IKl in single cells isolated from guinea pig and rabbit hearts.
RESULTS
At a clinically relevant concentration, CRL 50 mumol.L-1 inhibited the transient outward current (ITO) by 17.7% +/- 2.4% (n = 8) in rabbit atrial cells. The voltage-dependence of steady-state inactivation of ITO was not affected by CRL. This concentration of CRL did not influence the time-independent inward rectifier or the delayed rectifier K+ currents (IKl and IK, respectively) in rabbit and guinea pig ventricular cells.
CONCLUSION
CRL inhibited ITO, but not IK nor IKl.
目的
阐明常咯啉（CRL）是否改变心肌细胞中的钾电流（瞬时外向电流ITO、延迟整流钾电流IK和内向整流钾电流IKl）。
方法
采用高阻封接全细胞膜片钳技术记录从豚鼠和兔心脏分离的单个细胞中的ITO、IK和IKl。
结果
在临床相关浓度下，50μmol·L-1的CRL使兔心房细胞的瞬时外向电流（ITO）抑制了17.7%±2.4%（n = 8）。ITO稳态失活的电压依赖性不受CRL影响。该浓度的CRL对兔和豚鼠心室细胞中的非时间依赖性内向整流器或延迟整流钾电流（分别为IKl和IK）无影响。
结论
CRL抑制ITO，但不抑制IK和IKl。
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