大鼠胃内给予依普黄酮固体分散体的药代动力学
Pharmacokinetics of intragastric ipriflavone solid dispersion in rats.
作者信息
Li Y P, Zhou J J, Zhang X Y, Pei Y Y
机构信息
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 200031, China.
出版信息
Zhongguo Yao Li Xue Bao. 1999 Nov;20(11):1035-8.
AIM
To evaluate pharmacokinetic behavior of ipriflavone solid dispersion in rats.
METHODS
The plasma concentrations of ipriflavone in rats were determined by HPLC with UV detector.
RESULTS
Plasma concentration-time curves after ig ipriflavone solid dispersion 250 mg.kg-1 in rats were fitted with one-compartment model. Pharmacokinetic parameters were as follows: Ke = 0.21 h-1, T1/2Ke = 5.19 h, Ka = 1.71 h-1, T1/2Ka = 0.41 h, Tmax = 0.67 h, Cmax = 429 micrograms.L-1, AUC = 3916 micrograms.h.L-1; The relative bioavailability of ipriflavone solid dispersion was 323%.
CONCLUSION
Ipriflavone in solid dispersion was absorbed more effectively than that in physical mixture in rats.
目的
评估大鼠中依普黄酮固体分散体的药代动力学行为。
方法
采用带紫外检测器的高效液相色谱法测定大鼠血浆中依普黄酮的浓度。
结果
大鼠灌胃250mg·kg-1依普黄酮固体分散体后的血药浓度-时间曲线符合一室模型。药代动力学参数如下：消除速率常数（Ke）=0.21h-1，消除半衰期（T1/2Ke）=5.19h，吸收速率常数（Ka）=1.71h-1，吸收半衰期（T1/2Ka）=0.41h，达峰时间（Tmax）=0.67h，峰浓度（Cmax）=429μg·L-1，药时曲线下面积（AUC）=3916μg·h·L-1；依普黄酮固体分散体的相对生物利用度为323%。
结论
在大鼠中，依普黄酮固体分散体比物理混合物中的依普黄酮吸收更有效。
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