Li Y P, Zhang X Y, Zhou J J, Pei Y Y
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 200031, China.
Zhongguo Yao Li Xue Bao. 1999 Oct;20(10):957-60.
To prepare and identify ipriflavone (IP) solid dispersion, and determine its dissolution property.
The solvent method was used for preparation and differential scanning calorimetry (DSC), X-ray diffraction and infrared spectrophotometry for identification of IP solid dispersion. The dissolution of the dispersion was determined with paddle method.
The dissolution of IP solid dispersion consisting of IP and povidone-k30 (PVP) (1:8) in artificial gastric juice is 6.15 times as high as that of IP alone. The DSC curves, X-ray diffraction patterns and infrared spectrophotometries of IP have been changed obviously by the dispersion.
The dissolution of IP is increased by solid dispersion method.
制备并鉴定依普黄酮（IP）固体分散体，并测定其溶出特性。
采用溶剂法制备IP固体分散体，并用差示扫描量热法（DSC）、X射线衍射法和红外分光光度法进行鉴定。采用桨法测定分散体的溶出度。
由IP与聚维酮K30（PVP）（1∶8）组成的IP固体分散体在人工胃液中的溶出度是IP原料药的6.15倍。分散体使IP的DSC曲线、X射线衍射图谱和红外光谱发生了明显变化。
固体分散体法提高了IP的溶出度。
