Hughes M, Binning A
Department of Anaesthetics, Royal Infirmary, Glasgow, Scotland.
Intensive Care Med. 2000 Dec;26(12):1730-9. doi: 10.1007/s001340000668.
Amiodarone is widely used in intensive care units for the treatment of a variety of arrhythmias. It is currently the drug of choice for supraventricular tachyarrhythmias in many units because of its combination of efficacy and safety. This review summarises the current state of knowledge regarding the short-term administration of intravenous amiodarone to control arrhythmias in perioperative, coronary care and intensive care patients. It outlines the electrophysiology, haemodynamics, pharmacokinetics and toxicity of the drug. In particular, it examines the recent concerns regarding acute pulmonary toxicity.
胺碘酮在重症监护病房中被广泛用于治疗各种心律失常。由于其疗效和安全性兼具，目前在许多科室它是室上性快速心律失常的首选药物。这篇综述总结了关于静脉注射胺碘酮短期给药以控制围手术期、冠心病监护病房及重症监护病房患者心律失常的当前知识状况。文中概述了该药物的电生理学、血流动力学、药代动力学及毒性。特别是，探讨了近期对急性肺毒性的关注。
