Ichikawa Y, Fujimoto N, Hashimoto M, Kyo M, Kinoshita T, Takahara S, Yamasaki M, Ohshima S, Ihara H, Fukunishi T, Sata M, Amemiya H P, Hanafusa T, Nagano S
Department of Urology and Kidney Transplant Center, Hyogo Prefectural Nishinomiya Hospital, Japan.
Transpl Int. 1994;7 Suppl 1:S281-5. doi: 10.1111/j.1432-2277.1994.tb01367.x.
The study of a two-locus association between HLA-B and -DRB 1 revealed a significant 43 linkage disequilibrium. Donor-recipient HLA-DRB1 was determined by these 43 linkages. Zero-mismatch for HLA-DRB1 had a significant effect on the graft survival rate in living related and cadaver transplants. The 5-year graft survival rate was 94% in the zero-mismatch group for HLA-DRB1, 96% for related transplants, 92% for cadaver cases, and 94% in HLA identical siblings. A statistically significant difference was found between the zero-mismatch group for HLA-DRB1 and mismatch groups for HLA-DRB1 or HLA-DR (P < 0.01). The zero-mismatch group for HLA-DRB1 had mismatches for HLA-A and/or HLA-B in 46 of 70 cases (66%). No significant differences in the rejection rate was observed between zero-mismatch and mismatch cases for HLA-A and/or -B in the zero-mismatch group for HLA-DRB1. In the second step, genotyping was conducted in 118 cases. The 5-year graft survival rate was 93% in the zero-mismatch group for HLA-DRB1 and 86% in mismatch group (not a significant difference). We concluded that zero-mismatch transplant for HLA-DRB1 had a better long-term graft survival rate regardless of HLA class I.
对HLA - B和 - DRB1之间双位点关联的研究揭示了显著的连锁不平衡。供体 - 受体HLA - DRB1由这些连锁关系确定。HLA - DRB1零错配对于活体亲属移植和尸体移植的移植物存活率有显著影响。HLA - DRB1零错配组的5年移植物存活率为94%，亲属移植为96%，尸体移植为92%，HLA相同的同胞为94%。在HLA - DRB1零错配组与HLA - DRB1或HLA - DR错配组之间发现有统计学显著差异（P < 0.01）。HLA - DRB1零错配组在70例中有46例（66%）存在HLA - A和/或HLA - B错配。在HLA - DRB1零错配组中，HLA - A和/或 - B零错配与错配病例之间的排斥率未观察到显著差异。在第二步中，对118例进行了基因分型。HLA - DRB1零错配组的5年移植物存活率为93%，错配组为86%（无显著差异）。我们得出结论，无论HLA I类如何，HLA - DRB1零错配移植具有更好的长期移植物存活率。
