肾或心脏移植后非霍奇金淋巴瘤：移植后第一年的发生率

Non-Hodgkin's lymphoma after kidney or heart transplantation: frequency of occurrence during the first posttransplant year.

作者信息

Opelz G, Schwarz V, Henderson R, Kneifel G, Ruhenstroth A

机构信息

Institute of Immunology, University of Heidelberg, Germany.

出版信息

Transpl Int. 1994;7 Suppl 1:S353-6. doi: 10.1111/j.1432-2277.1994.tb01390.x.

DOI:10.1111/j.1432-2277.1994.tb01390.x

PMID:11271250

Abstract

The incidence of non-Hodgkin's lymphoma was analysed in over 70,000 kidney transplant recipients and over 10,000 heart, heart-lung or lung transplant recipients. An increased incidence of lymphomas during the first posttransplant year was observed in cadaver kidney recipients as compared to related kidney recipients, in thoracic organ recipients as compared to kidney recipients, in heart-lung recipients as compared to heart or lung recipients, in patients transplanted in North America as compared to patients transplanted in Europe, in patients receiving cyclosporine in combination with azathioprine as compared to patients with other immunosuppressive regimens, and in patients receiving ATG/ALG or monoclonal OKT3 for rejection prophylaxis.

摘要

对70000多名肾移植受者以及10000多名心脏、心肺或肺移植受者的非霍奇金淋巴瘤发病率进行了分析。观察到，与亲属肾移植受者相比，尸体肾移植受者在移植后第一年淋巴瘤发病率增加；与肾移植受者相比，胸器官移植受者发病率增加；与心脏或肺移植受者相比，心肺移植受者发病率增加；与欧洲的移植患者相比，北美移植患者发病率增加；与采用其他免疫抑制方案的患者相比，接受环孢素联合硫唑嘌呤治疗的患者发病率增加；以及与采用其他预防排斥反应方法的患者相比，接受抗胸腺细胞球蛋白/抗淋巴细胞球蛋白或单克隆OKT3治疗的患者发病率增加。