Mazzaferro V, Socci C, Regalia E, Andreola S, Di Bartolomeo M, Bertuzzi F, Di Carlo V, Pozza G, Doci R, Bozzetti F, Gennari L
Department of Surgery, Istituto Nazionale Tumori, Milan, Italy.
Transpl Int. 1994;7 Suppl 1:S409-11. doi: 10.1111/j.1432-2277.1994.tb01405.x.
We report a 1-year patient and graft survival after combined liver-pancreatic islet transplantation. The patient was affected by a pancreatic neuroendocrine carcinoma with extensive liver metastasis. Native pancreas and total liver removal was undertaken after a good response to chemotherapy, and the patient was still cancer-free 1 year later. Normal liver function and insulin independence was achieved, although islet response to glucose challenge remained delayed. Immunosuppression was maintained with cyclosporin monotherapy.
我们报告了肝胰联合胰岛移植术后1年的患者及移植物存活率。该患者患有胰腺神经内分泌癌并伴有广泛肝转移。在对化疗反应良好后进行了自体胰腺和全肝切除，1年后患者仍无癌症。尽管胰岛对葡萄糖刺激的反应仍然延迟，但实现了正常肝功能和胰岛素非依赖。免疫抑制采用环孢素单一疗法维持。
