Satter L D, Lang R L, Van Loo J W, Carlson M E, Kepler R W
J Dairy Sci. 1975 Apr;58(4):521-5. doi: 10.3168/jds.S0022-0302(75)84601-7.
The toxicity of DL-methionine and methionine hydroxy analog infused into the rumen or abomasum was gauged by relative feed consumption. A continuous intraruminal infustion of at least 3 days' duration of DL-methionine equalent to about 2.5% or more of dietary dry matter intake was required to reach a toxic amount. This was approximately four times the amount necessary when it was infused into the abomasum. Methionine hydroxy analog equalent to about 1% or more of dietary dry matter intake was toxic when infused into either rumen or abomasum. This is in large excess of suggested amounts of analog supplementation. Reduced palatability is likely to occur in advance of reduced intake due to toxicity.
通过相对采食量来评估注入瘤胃或皱胃的DL-蛋氨酸和蛋氨酸羟基类似物的毒性。连续向瘤胃内注入至少持续3天的相当于日粮干物质摄入量约2.5%或更多的DL-蛋氨酸，才能达到中毒量。这大约是注入皱胃时所需量的四倍。当注入瘤胃或皱胃时，相当于日粮干物质摄入量约1%或更多的蛋氨酸羟基类似物具有毒性。这大大超过了建议的类似物补充量。在因毒性导致采食量下降之前，适口性可能就已经降低。
