Lerakis S, Robert Taylor W, Lynch M, Litman C M, Clements S D, Thompson T D, Martin R P
Department of Medicine, Emory University School of Medicine and the Atlanta VA Medical Center, Georgia, USA.
Am J Med Sci. 2001 Feb;321(2):152-5. doi: 10.1097/00000441-200102000-00007.
Aortic valve abscesses (AVAs) are a devastating complication of aortic valve endocarditis. Over 8 years, 25 patients were diagnosed with AVA by transesophageal echo (TEE). Management and outcomes were then analyzed. Eleven (44%) AVAs involved prosthetic valves, and 6 (24%) occurred in congenitally malformed valves. Twenty patients (80%) underwent surgical intervention; the rest were treated medically. Eleven (44%) of the patients died [6 (30%) surgery patients and all the medical patients]. Eight of 11 (73%) patients who died were culture positive for Staphylococcus aureus. All patients with congenitally malformed aortic valves underwent surgical intervention and survived. We conclude that: (1) despite advances in therapy and diagnosis, patients with AVAs have a high mortality rate; (2) prognosis with AVA is especially poor when S aureus is the infectious organism; (3) patients with AVAs in congenitally malformed valves have a great outcome with surgery; (4) patients treated medically have a very poor prognosis; earlier identification by TEE may be critical to improving survival.
主动脉瓣脓肿(AVA)是主动脉瓣心内膜炎的一种严重并发症。在8年期间,通过经食管超声心动图(TEE)诊断出25例AVA患者。随后对其治疗及预后情况进行了分析。11例(44%)AVA累及人工瓣膜,6例(24%)发生于先天性畸形瓣膜。20例(80%)患者接受了手术干预;其余患者接受药物治疗。11例(44%)患者死亡[6例(30%)手术患者及所有接受药物治疗的患者]。死亡的11例患者中有8例(73%)金黄色葡萄球菌培养呈阳性。所有先天性主动脉瓣畸形患者均接受了手术干预且存活。我们得出以下结论:(1)尽管在治疗和诊断方面取得了进展,但AVA患者的死亡率仍然很高;(2)当感染病原体为金黄色葡萄球菌时,AVA的预后尤其差;(3)先天性畸形瓣膜合并AVA的患者手术效果良好;(4)接受药物治疗的患者预后很差;通过TEE早期识别对于提高生存率可能至关重要。