乳腺混合性大汗腺/内分泌导管原位癌与小叶原位癌共存。
Mixed apocrine/endocrine ductal carcinoma in situ of the breast coexistent with lobular carcinoma in situ.
作者信息
Coyne J D, Dervan P A, Barr L, Baildam A D
机构信息
Department of Pathology, South Manchester University NHS Trust, Withington Hospital, Nell Lane, Manchester M20 2LR, UK.
出版信息
J Clin Pathol. 2001 Jan;54(1):70-3. doi: 10.1136/jcp.54.1.70.
Abstract
An unusual mixed form of ductal carcinoma in situ (DCIS) of the breast is described, which exhibits a biphenotypic morphology encompassing a range of differential diagnostic DCIS subtypes. In addition, immunophenotypic and ultrastructural studies demonstrate neuroendocrine and apocrine differentiation, raising questions regarding appropriate classification and biological behaviour. In two cases, coexistence of this mixed form of DCIS with lobular carcinoma in situ (LCIS) in the same duct lobular units is an additional unusual feature that might, at least in some cases, indicate a closer relation between them.
摘要
本文描述了一种不寻常的乳腺原位导管癌（DCIS）混合形式，其表现出双表型形态，涵盖了一系列可鉴别诊断的DCIS亚型。此外，免疫表型和超微结构研究显示出神经内分泌和大汗腺分化，这引发了关于适当分类和生物学行为的问题。在两例病例中，这种DCIS混合形式与同一导管小叶单位中的小叶原位癌（LCIS）共存是另一个不寻常的特征，这至少在某些情况下可能表明它们之间存在更密切的关系。
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