Kharb S, Singh V, Ghalaut P S, Singh G P
Department of Biochemistry, Pt BD Sharma PGIMS, Rohtak, India.
J Assoc Physicians India. 2000 Jun;48(6):578-80.
Treatment with thrombolysis plays a crucial role in salvaging the myocardium in myocardial infarction (MI) patients, but reperfusion of ischaemic areas may itself be associated with reperfusion injury mediated by free radical induced oxidation. Hence the present study was planned to evaluate oxidative stress in patients receiving thrombolytic therapy during MI and to compare them with those not receiving thrombolysis.
Thiobarbituric acid reactive substance (TBARS) was used as a marker of lipid peroxidation in 30 patients after acute MI. Thirteen were treated by intravenous thrombolysis and 17 served as control. Also, vitamin E levels were estimated in these patients.
Patients treated with thrombolysis showed a fall in vitamin E and increase in TBARS within first hours. The decrease in vitamin E was independent of a change in cholesterol. However, the levels were similar at 72 hours.
The results indicate increased free radical production after MI and reperfusion also increases in free radical production and antioxidants may have a part in improving thrombolytic reperfusion of ischaemic myocardium.
溶栓治疗在挽救心肌梗死（MI）患者的心肌方面起着关键作用，但缺血区域的再灌注本身可能与自由基诱导氧化介导的再灌注损伤有关。因此，本研究旨在评估MI期间接受溶栓治疗患者的氧化应激，并将其与未接受溶栓治疗的患者进行比较。
在30例急性MI患者中，使用硫代巴比妥酸反应性物质（TBARS）作为脂质过氧化的标志物。13例接受静脉溶栓治疗，17例作为对照。此外，还对这些患者的维生素E水平进行了评估。
接受溶栓治疗的患者在最初几小时内维生素E水平下降，TBARS水平升高。维生素E的下降与胆固醇变化无关。然而，72小时时水平相似。
结果表明MI后自由基产生增加，再灌注也会增加自由基产生，抗氧化剂可能在改善缺血心肌的溶栓再灌注方面发挥作用。
