Nakamura K, Kurasawa M
CNS Supporting Laboratory, Nippon Roche Research Center, 200 Kajiwara, Kamakura, Kanagawa 247-8530, Japan.
Pharmacol Biochem Behav. 2001 Jan;68(1):65-9. doi: 10.1016/s0091-3057(00)00440-8.
This study aims to examine the effects of aniracetam on satiation-induced poor performance in a choice reaction task. Aged rats that mastered the task under food restriction stably maintained the task performance for a long period. Satiation by successive free feeding greatly diminished the performance. Satiation resulted in a decreased % correct, increased % omission and prolonged choice reaction time, indicating a reduction in lever response with low choice accuracy and slow responding speed. Repeated administration of aniracetam (30 mg/kg, po, for 14 days) partially recovered the choice accuracy and lever response, but not the responding speed, task-associated motor activity or impulsivity. In addition, aniracetam did not affect the animals' weights. These results indicate that satiation reduces motivation to perform and attain the task. Aniracetam may restore motivation, probably by improving poor behavioral states (daily attentional and vigilance failures), thereby creating the driving force.
本研究旨在探讨阿尼西坦对选择反应任务中饱食诱导的行为表现不佳的影响。在食物限制条件下掌握该任务的老年大鼠能够长期稳定地维持任务表现。连续自由进食导致的饱食会极大地降低任务表现。饱食导致正确百分比降低、遗漏百分比增加以及选择反应时间延长，表明杠杆反应减少，选择准确性低且反应速度慢。重复给予阿尼西坦（30毫克/千克，口服，持续14天）可部分恢复选择准确性和杠杆反应，但不能恢复反应速度、与任务相关的运动活动或冲动性。此外，阿尼西坦不影响动物体重。这些结果表明，饱食会降低执行和完成任务的动机。阿尼西坦可能通过改善不良行为状态（日常注意力和警觉性下降）来恢复动机，从而产生驱动力。
