Koyama T, Kato K, Tanaka Y Z, Mikami A
Department of Behavioral and Brain Sciences, Primate Research Institute, Kyoto University, Inuyama, Aichi 484-8506, Japan.
Neurosci Res. 2001 Apr;39(4):421-30. doi: 10.1016/s0168-0102(01)00197-3.
We recorded single neuronal activities in the anterior cingulate cortex of monkeys while they were performing discriminative pain-avoidance and reward tasks: a prediction cue was presented for 0.5-1.5 s, followed by a red or green discrimination cue (1:1, random) for 1.0 s; painful stimuli were presented if the monkey failed to respond during the red cue; a reward was given, subsequent to a cued 1 s delay, if the monkey responded after the green cue. Among 775 neurons recorded, 196 neurons showed significant activity during one or more observation periods; 36 during the prediction period; 77 during the discrimination period; 41 during the delay period; 85 during the response period; 40 during the pre-reward period; and 15 during the reward-ingestion period. Of 77 neurons activated during the discrimination period, 47 showed exclusive activity either during the red (34) or during the green (13) cue: of 85 neurons activated during the response period, 64 showed exclusive activity either for pain-avoidance (37) or obtaining a reward (27). Control experiments confirmed that the neuronal activity could not be attributed to simple visual or motor processes. The results suggest that some anterior cingulate neurons are involved with anticipation of, and response selection for, imminent events.
我们记录了猴子前扣带皮层的单个神经元活动，同时它们执行辨别性疼痛回避和奖励任务：呈现一个预测线索0.5 - 1.5秒，随后是红色或绿色辨别线索（1:1，随机）1.0秒；如果猴子在红色线索期间没有做出反应，则呈现疼痛刺激；如果猴子在绿色线索后做出反应，在提示的1秒延迟后给予奖励。在记录的775个神经元中，196个神经元在一个或多个观察期内表现出显著活动；预测期内有36个；辨别期内有77个；延迟期内有41个；反应期内有85个；奖励前时期内有40个；奖励摄取期内有15个。在辨别期激活的77个神经元中，47个在红色（34个）或绿色（13个）线索期间表现出排他性活动：在反应期激活的85个神经元中，64个在疼痛回避（37个）或获得奖励（27个）时表现出排他性活动。对照实验证实，神经元活动不能归因于简单的视觉或运动过程。结果表明，一些前扣带神经元参与对即将发生事件的预期和反应选择。
