Lapalus M G, Gaudin J L, Lemkecher T, Souquet J C, Wendehenne F, Peltrault C, Pontette F, Pillon M, Monier J M, Dumont O
Service d'Hépato-Gastroentérologie, Hôpital de la Croix-Rousse, CHU, Lyon.
Gastroenterol Clin Biol. 2001 Jan;25(1):29-34.
The aim of this prospective, randomized, study performed in 60 outpatients was to compare 2 precolonoscopy bowel preparations: oral sodium phosphate (NaP) versus standard polyethylene glycol-based lavage solution (PEG). None of the patients met any of NaP exclusion criteria. All patients were prepared on the day prior to colonoscopy. A patient-questionnaire and measure of serum electrolytes (calcium, phosphate, sodium, potassium), pulse and blood pressure were used to assess tolerance and acceptability of the preparation. The quality of colon cleansing was judged by blinded endoscopists.
Patient's tolerance to NaP was superior to PEG: NaP preparation was easier to drink and feelings of abdominal plenitude occurred in a smaller proportion of patients. A potassium decrease, a sodium increase and hyperphosphatemia were observed in the NaP group but without clinical events. PEG preparation seemed to allow a better cleansing ability compared with NaP but this difference was not statistically significant.
NaP solution was better tolerated and accepted by patients. Colonic preparation quality compared to PEG is still to be discussed depending on the intake schedule. A biochemical data check seems necessary on account of significant serum electrolytes changes induced by NaP preparation.
这项针对60名门诊患者的前瞻性随机研究旨在比较两种结肠镜检查前肠道准备方法：口服磷酸钠（NaP）与标准聚乙二醇灌肠液（PEG）。所有患者均不符合NaP排除标准。所有患者均在结肠镜检查前一天进行准备。采用患者问卷以及血清电解质（钙、磷、钠、钾）、脉搏和血压测量来评估准备方法的耐受性和可接受性。结肠镜清洁质量由不知情的内镜医师判断。
患者对NaP的耐受性优于PEG：NaP制剂更容易饮用，且出现腹部饱胀感的患者比例较小。NaP组观察到血钾降低、血钠升高和高磷血症，但未发生临床事件。与NaP相比，PEG制剂似乎具有更好的清洁能力，但这种差异无统计学意义。
患者对NaP溶液的耐受性和接受度更好。与PEG相比，结肠准备质量仍需根据摄入方案进行讨论。鉴于NaP制剂引起显著的血清电解质变化，似乎有必要进行生化数据检查。
