Simmons D L, Legore A A, Picotte P, Lee K S, Joshi N N
J Pharmacokinet Biopharm. 1975 Feb;3(1):39-49. doi: 10.1007/BF01066594.
An apparatus utilizing liquid turbulence to simulate hydrodynamic conditions generated by gastrointestinal peristalsis was designed to estimate drug release from solid oral dosage forms; This turbulence was achieved through special arrangements of a pipetting pump to a dissolution chamber. By adjusting the flow rate of the pump to deliver and withdraw a fixed volume of dissolution medium per minute, a correlation was developed between dissolution rates and absorption patterns in beagles of two commerical tolbutamide tablets, A and B, and a micronized tolbutamide suspensionmon the basis of this relationship, it was possible to predict the initial absorption patterns of two misformulated tablets, C and D.
设计了一种利用液体湍流来模拟胃肠道蠕动产生的流体动力学条件的装置，以评估固体口服剂型的药物释放；这种湍流是通过将移液泵以特殊方式连接到溶出室来实现的。通过调节泵的流速，使其每分钟输送和抽取固定体积的溶出介质，得出了两种市售甲苯磺丁脲片剂A和B以及一种微粉化甲苯磺丁脲混悬液在比格犬体内的溶出速率与吸收模式之间的相关性。基于这种关系，可以预测两种配方错误的片剂C和D的初始吸收模式。
