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乳腺癌的皮肤转移在临床上与无肌病性皮肌炎难以区分。

Skin metastasis of breast cancer clinically undistinguished from amyopathic dermatomyositis.

作者信息

Seishima M, Shimizu H, Oyama Z

机构信息

Department of Dermatology, Ogaki Municipal Hospital, Minaminokawa-cho 4-86, Ogaki, 503-8502, Japan.

出版信息

Eur J Dermatol. 2001 Mar-Apr;11(2):131-3.

Abstract

We report a 65-year-old woman who consulted us on May 25, 1998, showing pruritic, partially flagellate erythema on the back and upper extremities, livedo lesions with erythema on the loins, and erythematous papules on the dorsal finger joints for 2 months. Histopathological findings of erythema on the back showed mononuclear cell infiltration around capillaries and marked edema in the dermis. Laboratory data were within normal range except for positive anti-nuclear antibody. She had undergone total left mastectomy on June 2, 1997 for breast cancer. Supraclavicular lymph node metastasis was found at the beginning of May, 1998. A diagnosis of amyopathic dermatomyositis associated with breast cancer was made. Erythema with itching gradually subsided from the end of August, 1998. Treatment with radiation and chemotherapy reduced lymph node swelling, but complete remission was not obtained. Erythema similar to the previous lesion but without itching re-appeared on the back from January, 2000. Histological findings of erythema showed many carcinoma cells similar to the primary lesion of left breast cancer in the whole dermis. A diagnosis of skin metastasis of breast cancer was made. These findings suggest that skin metastasis should be taken into account for patients with erythema on the trunk similar to dermatomyositis.

摘要

我们报告一名65岁女性,她于1998年5月25日前来就诊,背部和上肢出现瘙痒性、部分呈鞭状的红斑,腰部有青斑样损害伴红斑,以及指背关节处有红斑丘疹,持续2个月。背部红斑的组织病理学检查结果显示毛细血管周围有单核细胞浸润,真皮层有明显水肿。除抗核抗体阳性外,实验室检查数据均在正常范围内。她于1997年6月2日因乳腺癌接受了左侧乳房全切术。1998年5月初发现锁骨上淋巴结转移。诊断为与乳腺癌相关的无肌病性皮肌炎。1998年8月底,伴有瘙痒的红斑逐渐消退。放疗和化疗使淋巴结肿胀减轻,但未完全缓解。2000年1月,背部再次出现与之前类似但无瘙痒的红斑。红斑的组织学检查结果显示整个真皮层有许多与左侧乳腺癌原发灶相似的癌细胞。诊断为乳腺癌皮肤转移。这些发现提示,对于躯干出现类似皮肌炎红斑的患者,应考虑皮肤转移的可能。

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