Aslanidis Spyros, Pyrpasopoulou Athina, Kartali Nikoleta, Zamboulis Chryssanthos
B' Propaedeutic Department of Internal Medicine, Hippokration General Hospital, Konstantinoupoleos 49, Thessaloniki 54642, Greece.
Clin Rheumatol. 2007 Jul;26(7):1198-200. doi: 10.1007/s10067-006-0337-8. Epub 2006 May 31.
Skin involvement in dermatomyositis does not always parallel muscle disease and can be the most active or severe component of the disease, failing to respond to therapeutic interventions that are adequate for myositis and other systemic involvement. This case refers to a resistant paraneoplastic amyopathic dermatomyositis rash which readily resolved with intravenous immunoglobulin (IVIG), practically in the form of monotherapy. This observation gains particular significance considering that IVIG is still regarded as a second-line therapeutic regimen in the treatment of dermatomyositis despite its prevalence in matters of safety.
皮肌炎中的皮肤受累情况并不总是与肌肉疾病平行，它可能是该疾病最活跃或最严重的组成部分，对治疗肌炎和其他全身受累有效的治疗干预措施往往对其无效。本病例指的是一种难治性副肿瘤性无肌病性皮肌炎皮疹，静脉注射免疫球蛋白（IVIG）几乎以单一疗法的形式使其迅速消退。鉴于尽管IVIG在安全性方面具有优势，但在皮肌炎治疗中仍被视为二线治疗方案，这一观察结果具有特殊意义。
