Kanny G, Marie B, Hoen B, Trechot P, Moneret-Vautrin D A
Service de Médecine D, Médecine Interne, Immunologie Clinique et Allergologie, CHU de Nancy, Hôpital Central, 29, avenue de Lattre-de-Tassigny, 54035 Nancy Cedex, France.
Eur J Dermatol. 2001 Mar-Apr;11(2):134-7.
A patient had a maculopapular rash, fever, hepatic cytolysis, rhabdomyolysis, eosinophilia and raised total IgEs after coronarography with ioxaglic acid-meglumine (Hexabrix). Intradermal test to ioxaglic acid-meglumine was positive 48 hrs later. Histological examination revealed perivascular lymphocytic infiltration, with predominantly CD45Ro+ and CD8+ T cells and apoptotic basal keratinocytes. This case documents a late hypersensitivity reaction to ioxaglic acid-meglumine.
