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Dehydration of tetracycline.

作者信息

Schlecht K D, Frank C W

出版信息

J Pharm Sci. 1975 Feb;64(2):352-4. doi: 10.1002/jps.2600640241.

Abstract

The dehydration of tetracycline at the C-5a-C-6 position as a function of acidity was investigated at various temperatures. The rate was first order with respect to tetracycline and with respect to [H+]. Rate constants and an activation energy are reported. Tetracycline was unstable in dilute acid.

摘要

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