Nangia M, Syed W, Doraiswamy P M
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA.
Public Health Nutr. 2000 Dec;3(4A):487-94. doi: 10.1017/s1368980000000562.
Extracts of St. John's wort have been widely used in the treatment of depression. Our aim was to review information related to the efficacy and safety of St. John's wort as an antidepressant.
Primary and review articles were identified by a search of Medline (1960 to February 2000) and through secondary sources.
All the articles identified from the data sources were evaluated and all relevant information was included in this review. The pharmacokinetics, mechanism of action, efficacy, side effects and drug interactions of St. John's wort have been examined in various studies.
St. John's wort is a promising investigational antidepressant, but the data are not yet sufficient to accept hypericum as a first line antidepressant preparation for treatment of depression. Besides the need for dose standardization and adequate trial lengths, there is a need for studies in severely depressed patients and long-term studies to assess the risk of relapse and recurrence.
圣约翰草提取物已广泛用于治疗抑郁症。我们的目的是综述与圣约翰草作为抗抑郁药的疗效和安全性相关的信息。
通过检索Medline（1960年至2000年2月）以及二手资料确定了原始文章和综述文章。
对从数据来源中识别出的所有文章进行了评估，并将所有相关信息纳入本综述。在各种研究中考察了圣约翰草的药代动力学、作用机制、疗效、副作用及药物相互作用。
圣约翰草是一种有前景的抗抑郁研究药物，但现有数据尚不足以将金丝桃属植物制剂作为治疗抑郁症的一线抗抑郁药。除了需要进行剂量标准化和足够长的试验外，还需要对重度抑郁症患者进行研究以及开展长期研究以评估复发风险。
