Swedlow J R, Lamond A I
Division of Gene Regulation and Expression, Wellcome Trust Biocentre, University of Dundee, Dow Street, Dundee, DD1 5EH, UK.
Genome Biol. 2001;2(3):REVIEWS0002. doi: 10.1186/gb-2001-2-3-reviews0002. Epub 2001 Mar 9.
DNA is highly organized spatially, both within domains of chromatin along each chromosome and within the nucleus as a whole. Recent studies suggest that chromatin localization can affect transcriptional and replicational activity. The similarity between the movements of chromatin nuclear bodies suggests a common mechanism that regulates nuclear dynamics.
DNA在空间上高度有序，既存在于每条染色体上染色质结构域内，也存在于整个细胞核内。最近的研究表明，染色质定位可影响转录和复制活性。染色质核体运动之间的相似性表明存在一种调节核动力学的共同机制。
