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人类智力的数量遗传学与分子遗传学

The quantitative and molecular genetics of human intelligence.

作者信息

McGuffin P

机构信息

Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College London, De Crespigny Park, Denmark Hill, London SE5 8AF, UK.

出版信息

Novartis Found Symp. 2000;233:243-55; discussion 255-9, 276-80. doi: 10.1002/0470870850.ch15.

Abstract

General cognitive ability or g as measured by IQ tests has been the most intensively studied trait in human behaviour genetics. Although there has been much debate about how best to describe and measure intelligence, this is addressed elsewhere in this volume and here I will assume that there is utility in the concept of general intelligence and review the data showing that, whatever it is, g is familial and influenced by genes. Next, I will briefly describe some of the main quantitative genetics models that have been used in trying to tease out the genetic and environmental sources of variation. Finally, I will outline current molecular genetic research aiming to locate and identify genes influencing human intelligence and try to predict the directions in which such research will lead.

摘要

通过智商测试衡量的一般认知能力,即g,一直是人类行为遗传学中研究最深入的特质。尽管对于如何最好地描述和测量智力存在诸多争议,但本卷其他地方会探讨这个问题,在此我将假定一般智力的概念是有用的,并回顾相关数据,这些数据表明,无论g是什么,它都具有家族遗传性且受基因影响。接下来,我将简要描述一些主要的数量遗传学模型,这些模型被用于梳理变异的遗传和环境来源。最后,我将概述当前旨在定位和识别影响人类智力的基因的分子遗传学研究,并尝试预测此类研究的发展方向。

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