Korczyn A D, Goldberg G J
J Neurol Neurosurg Psychiatry. 1976 Sep;39(9):866-9. doi: 10.1136/jnnp.39.9.866.
A study was conducted on 66 psychiatric inpatients who took major tranquilizers for periods of four to 16 years. The frequency of signs of Parkinsonism and the effects of orphenadrine on these were studied in a double-blind crossover method. Sixty-one per cent of the patients showed signs of Parkinsonism. Female patients and those with organic brain pathology more frequently exhibited Parkinsonism (although the difference was not statistically significant). No correlation was found between duration of treatment and extrapyramidal effects. Of the 40 patients who developed Parkinsonism, 25 responded favourably to orphenadrine, while six (15%) had more marked manifestations on orphenadrine than on placebo.
对66名服用大剂量镇静剂4至16年的精神科住院患者进行了一项研究。采用双盲交叉法研究了帕金森氏症体征的发生率以及奥芬那君对这些体征的影响。61%的患者出现帕金森氏症体征。女性患者和患有器质性脑病变的患者更常出现帕金森氏症（尽管差异无统计学意义）。未发现治疗时间与锥体外系效应之间存在相关性。在出现帕金森氏症的40名患者中，25名对奥芬那君反应良好，而6名（15%）在服用奥芬那君时的表现比服用安慰剂时更为明显。
