吡喃共聚物的肿瘤抑制作用：与细胞毒性巨噬细胞产生的相关性。
Tumor suppression by pyran copolymer: correlation with production of cytotoxic macrophages.
作者信息
Harmel R P, zbar B
出版信息
J Natl Cancer Inst. 1975 Apr;54(4):989-92.
Intraperitoneal administration of pyran copolymer (pyran-2-succinic anhydride-4,5-dicarboxytetrahydro-6-methylanhydride polymer) protected C3H/HeN male mice against tumor development after intradermal challenge with cells of the transplantable, methylcholanthrene-induced, syngeneic fibrosarcoma 1038. Peritoneal cells from pyran-treated but not from normal animals suppressed tumor development in local passive-transfer experiments. Adherent peritoneal cells from pyran-treated mice were cytotoxic in vitro to several syngeneic murine tumor cell lines including 1038.
对C3H/HeN雄性小鼠腹腔注射吡喃共聚物（吡喃-2-琥珀酸酐-4,5-二羧基四氢-6-甲基酐聚合物），在用可移植的、甲基胆蒽诱导的同基因纤维肉瘤1038细胞进行皮内攻击后，可保护小鼠免于肿瘤发生。在局部被动转移实验中，来自经吡喃处理的动物而非正常动物的腹腔细胞可抑制肿瘤发生。来自经吡喃处理小鼠的贴壁腹腔细胞在体外对包括1038在内的几种同基因小鼠肿瘤细胞系具有细胞毒性。
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